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Celexa is an antidepressant drug used to treat depression associated with mood disorders. Celexa is an astonishing antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. Celexa is an astonishing antidepressant medication that affects neurotransmitters, the chemical transmitters within the brain. Celexa causes less drug interactions, you should always let your doctor know what other medications you are taking. Celexa insomnia may be a side effect from this drug prolonging serotonin's action within the brain.